| .鱼油多烯康胶囊对慢性肾衰病人血脂及肾功能的影响[J].中国海洋药物,1995,14(3):39-42. |
| 鱼油多烯康胶囊对慢性肾衰病人血脂及肾功能的影响 |
| EFFECTS OF MARINE FISH OIL ON THE PASMA LIPIDS AND RENAL FUNCTION IN PATIENTS WITH CRF |
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| DOI： |
| 中文关键词: 慢性 高脂血症 鱼油 多烯康 肾功能衰竭 |
| English Keywords:Chronic renal failure,hyperlipidemia,marine fish oil |
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| 中文摘要: |
| ２２例慢性肾衰病人在低蛋白饮食，降压等治疗基础上，予富含ＥＰＡ和ＤＨＡ的天然海鱼油制剂多烯康胶囊口服，８Ｗ后血甘油三酯和胆固醇分别降低２４．７％及１４．８％，高密度脂蛋白及载脂蛋白ＡＩ／载脂蛋白Ｂ比值提高，内发生肌酐清除率亦增加３９．６％，血清肌酐上升速率明显延缓，血浆游离氨基酸谱也有改善，结果表明，补充ω－３多烯脂肪酸改善血脂代谢紊乱，有利于迟缓慢性肾衰进展，可作为非透析治疗的辅助药物。 |
| English Summary: |
| We examined the effects of marine fish oil, which is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA),in 22 patients with chronic renal failure (CRF). At 8 weeks treatment,marine fish oil led to decreases in both plasma triglyceride ( -24. 7%) and cholesterol (-14. 8%),and increases in high density lipoprotein and the ratio of apolipoprotein Al/apolipoprotein B. Meanwhile, the endogeneous creatinine clearance was raised by 39. 6%,and the increasing rate of serum creatinine level was slowed down. We conclude that supplementation of co-3 polyunsaturated fatty acids can effectively improve the abnormalities of lipids metabolism in CRF. It is beneficial to retardation of progression of CRF,and to reduction of the risk of cardiovascular complications. We hold that marine fish oil can be used as a supplementary drug in the treatment of CRF. |
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