| .牛磺酸对豚鼠单一心室肌细胞钙离子电流的作用[J].中国海洋药物,1995,14(4):1-5. |
| 牛磺酸对豚鼠单一心室肌细胞钙离子电流的作用 |
| EFFECTS OF TAURINE ON CALCIUM CURRENT IN SINGLE VENTRICULAR CELLS OF GUINEA PIGS |
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| DOI： |
| 中文关键词: 牛磺酸 钙离子 电流 钙通道阻滞剂 膜片钳 |
| English Keywords:Taurine (Tau ),calcium current (Iea ),calcium channel blockade,patch clamp method |
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| 中文摘要: |
| 应用全细胞膜片钳制技术观察了牛磺酸对豚鼠单一心室肌细胞慢内向钙离子电流的作用，实验结果显示：牛磺酸能减少心室肌细胞的Ｃａ＾２＋内流。此作用具有明显的电压依赖性，对其反转电位无明显影响。 |
| English Summary: |
| With patch clamp method,the effects of taurine (Tau) on slow inward calcium current (Ica) were investigated in single ventricular cells of guinea pigs. Tau decreased Ica in a dose- and voltage-dependent mode,but had little effect on reversal potential. Tau 0. 1 umol - L-1 decreased Ica by 17% and its maximal effective concentration was near 100 umol -L '. The initial block of Tau had already reached by 47% after a rest out of stimulation. Tau facilitated the reduction of lea through increasing clamp pulse frequency. The obtained results suggested that it decreased Ica in a use-dependent manner. |
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