| .海洋肽的体外抗氧化作用[J].中国海洋药物,1998,17(3):15-17. |
| 海洋肽的体外抗氧化作用 |
| ANTIOXIDATIVE EFFECT OF POLYPEPTIDES FROM THE CHLAMYS FARRERl IN VITRO |
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| DOI： |
| 中文关键词: 栉孔扇贝 脂质过氧化 海洋肽 抗皮肤老化 |
| English Keywords:polypeptides from Chlamys farreri(PCF),lipid peroxides,free radical, |
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| 中文摘要: |
| 海洋肽系栉了孔扇贝中提取的多肽,分子量为800～1000。为研究其抗皮肤衰老的作用机制,测定了海洋肽对由邻苯三酚自氧化产生的超氧阴离子、Fenton反应产生羟自由基的清除率,过氧化脂质的最终分解产物丙二醛(MDA),油脂过氧化值(peroxide value,POV)。结果表明,海洋肽(3％,15％)对超氧阴离子的清除率分别为11.7％和41.8％,对羟自由基的清除率分别为8.6％和38.4％,与对照组比较差异有显著性(P<0.01)。同时,海洋肽(0.05％,0.50％)能降低5d和10d的POV和MDA含量(P<0.05,0.01)。实验证明,海洋肽通过有效清除超氧阴离子、羟自由基并抑制脂质过氧化而抗皮肤老化。 |
| English Summary: |
| The polypeptides (PCF) were isolated from Chlamys farreri (Mr 800 -
1000). The antioxidative mechanisms of PCF were studied in this paper. It has been shown that superoxide anion free radical and hydroxyl free radical were scavenged by PCF (3%, 15%). The oils and fats peroxide values (POV) and the contents of MDA were also determined. The results showed that the percentage scavenging superoxide anion free radical were 11- 7% and 41. 8% ,scavenging hydroxyl free radical were 8-6% and 38. 4% respectively. It could decrease the oils and fats POV and the contents of MDA in 5d and 10d(P<0. 05, 0. 01). The antioxidative mechanisms of PCF were that the superoxide anion radical and hydroxyl free radical could be inhibited effectively. |
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