| .J—911对实验性肝损伤的保护作用[J].中国海洋药物,1999,18(3):26-29. |
| J—911对实验性肝损伤的保护作用 |
| THE PROTECTIVE EFFECTS OF J-911 ON EXPERIMENTAL LIVER INJURY |
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| DOI： |
| 中文关键词: J－911 肝损伤 肝纤维化 动物实验 |
| English Keywords:J - 911, Ccl_4, D - galactosamine, acute liver injury, hepatic fibrosis |
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| 中文摘要: |
| 通过建立小鼠急性肝损伤及大鼠慢性肝损伤模型，观察并研究海洋药物Ｊ－９１１对小鼠急性肝损伤及大鼠慢性肝损伤的保护作用。结果表明，Ｊ－９１１能明显降低Ｄ－半乳糖胺引起急性肝损伤疡血清ＡＬＴ升高和四氯化碳引起的急性肝损伤小鼠的血清ＡＬＴ、ＡＳＴ的升高，明显减轻模型肝组织病理损伤。 |
| English Summary: |
| The projective effects of J - 911 on the acute liver injury in mice and the chronic liver in jury in rats were observed and studied by establishing animal models. The results showed that J - 911 sig nificantly decreased the elevation of serum ALT induced by Galn and the elevation of serum ALT. J - 911 markedly decreased the elevation of serum AST. ALT and hydroxyproline in liver tissue of hepatic fibrosis rats induced by ccl_4, the liver tissue injuries of hepatic fibrosis rats were also ameliorated. The results sug gest that J - 911 may have protective effects on experimental liver injury. |
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