| .牛磺酸对大鼠杏仁核点燃的作用[J].中国海洋药物,2000,19(1):14-16. |
| 牛磺酸对大鼠杏仁核点燃的作用 |
| EFFECT OF TAURINE ON THE AMYGDALAKINDLING IN RATS |
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| DOI： |
| 中文关键词: 牛磺酸 点燃模型 大鼠 杏仁核 癫痫 |
| English Keywords:taurine,kindling model,rat |
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| 中文摘要: |
| 用大鼠杏仁核点燃模型（Ｋｉｎｄｌｉｎｇ ｍｏｄｅｌ），研究牛磺酸对点燃发展进程及完全点燃的大鼠的作用。每日一次刺激大鼠右侧杏仁核（４０ｕＡ、６０ＨＺ、波宽１ｍｓ、矩形方波１秒），在１３次产生点燃效应的Ｖ期反应，刺激后放电时间显著延长。脑室注射牛磺酸２００ｕｇ、４００ｕｇ可显著抑制眯燃效应的Ｖ期反应（Ｐ〈０．０１），但对已点燃的大鼠无抑制作用。提示牛磺酸作为内源性的氨基酸神经递质，在预防癫痫的发展方 |
| English Summary: |
| To study the effects of taurine on amygdala kindling development and kindled seizures in rats. Electrical stimulation of the right amygdala (400uA, 60Hz, square wave for one sec) was given one time a day. An average of daily consecutive 13 stimulations was needed to reach the rirst V stage seizures, at which the rats showed behaviorial convulsions and electroencephalographic abnormalities. Intraceretroven-triculal injection of taurine (200ug, 400ug) significantly inhibited the amygdala kindling development (P<0.01),but no effect on fully kindled rats. It suggested that taurine had played an important role in preventing the forming and development of neurosis related to epilepsy. |
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