| .甲壳胺—三聚磷酸钠复合骨架微丸的研究[J].中国海洋药物,2002,21(2):34-38. |
| 甲壳胺—三聚磷酸钠复合骨架微丸的研究 |
| A study on the chitosan-tripolyphosphate sodium complex matrix Pellets |
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| DOI： |
| 中文关键词: 甲壳胺 三聚磷酸钠 聚电解质复合物 双氯灭痛 微丸 |
| English Keywords:Chitosan,sodium tripolyphosphate,polyelectrolyte,sodium diclofenac,pellets |
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| 中文摘要: |
| 目的：开发应用新辅料甲壳胺与三聚磷酸钠发生聚合反应，生成聚电解质复合物，作为骨架材料制备双氯灭痛微丸。方法：根据静电作用原理，制备甲壳烷－三聚磷酸钠电解质复合物，对其性质、结构特征等进行研究。考察双氯灭痛微丸的制备工艺，影响因素。结果：IR图谱峰值变化表明该复合物结构中含有一NH3^ 、OP^-基团。DTA图谱表明聚电解质复合物存在一个特征热峰，药物与辅料没有相互作用。SEM图谱表明微丸表面规整、致密、表面与内部结构不一致。微丸园整，丸径分布均匀一致，平均粒径10mm左右。结论：甲壳胺－三聚磷酸钠电解质复合物，可以作为制备微丸的复合骨架材料。 |
| English Summary: |
| VE: Chitosan and sodium tripolyphosphate were used as Complex matrix material for preparing pellets loading sodium diclofenac and its properties were studied. METHODS Chitosantripolyphosphate sodium polyelectrolyte was prepared according to the principle of static electricity polymerization. Its properties and structure characteristics were further investigated. The preparation process, effective factors and the optimal condition for the pellets loading sodium diclofenac were studied. RESULTS IR indicated that the structure of compound contained -NH3+-O-P group. DTA demonstrated that polyelectrolyte had an exothermic peak. There was no interaction between the drug and expedient. SEM showed that the surface of the pellets was regular, dense and the structure of the surface wasn't consistent with the inner. The pellets prepared by this method were uniform, round, well-distributed, hardy, good-mobility and its average diameter was about 10mm. CONCLUSION Chitosan-tripolyphosphate sodium polyelectrolyte could be used as a good matrix material for preparing pellets. |
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