| .海洋硫酸多糖911免疫增强作用的探讨[J].中国海洋药物,2002,21(5):1-4. |
| 海洋硫酸多糖911免疫增强作用的探讨 |
| A Study on Immunopotentiating Activity of Marine Sulfated Polysaccharide 911 |
| 修订日期：2001-11-12 |
| DOI： |
| 中文关键词: 海洋硫酸多糖 911 淋巴细胞 巨噬细胞 免疫调节作用 荧光染色 |
| English Keywords:marine sulfated polysaccharide 911,lymphocytes,macrophages,immunomodu- lating activity,fluorescent staining |
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| 中文摘要: |
| 分别观察了海洋硫酸多糖911对小鼠胸腺，脾脏淋巴细胞增殖反应的影响，以及对小鼠腹腔世噬细胞吞噬能力的影响，并应用911－FITC荧光探针对淋巴细胞和巨噬细胞进行了荧光染色，以寻找911的受体，探讨其免疫增强机制，结果表明，911的适宜剂量能较弱地刺激小鼠胸腺，脾脏淋巴细胞增殖，明显促进ConA诱导的T淋巴细胞及LPS诱导的BI林巴细胞增殖，显著增强小鼠腹腔巨噬细胞吞噬中性红的能力，且免疫细胞均能染上911－FITC，说明911能增强机体的免疫力，起到免疫调节作用，且免疫细胞上存在911的受体。 |
| English Summary: |
| In this paper, the influence of 911 to lymphocyte proliferation and peritoneal macro-phage phagocytosis was studied. Then thymocytes, splenocytes and macrophages were incubated with the fluorescent probe of 911-FITC to detect the receptors of 911 on immune cells. Results showed that proper dosage of 911 increased lymphocytes proliferation and phagocytic activity of macrophages significantly. Furthermore, 911-FITC bound to both lymphocytes and macrophages which showed that 911 had bound to its receptors on lymphocytes and macrophages and exerted its immunomodulating activity, accordingly. |
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