| .螺旋藻来源的γ-亚麻酸甲酯调血脂作用研究[J].中国海洋药物,2003,22(6):30-34. |
| 螺旋藻来源的γ-亚麻酸甲酯调血脂作用研究 |
| Studies on the hypolipidemic effects of gamma-linolenic acid methyl ester derived from Spirulina maxima |
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| DOI： |
| 中文关键词: γ-亚麻酸甲酯（GLAME） 调血脂 抗氧化 |
| English Keywords:gamma-linolenic acid methyl ester(GLAME),hypolipidemic effect,antioxidant effect, |
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| 中文摘要: |
| 利用从螺旋藻中提取的γ-亚麻酸甲酯(GLAME)，分别制成含GLAME0.25％、0．5％、1％的饲料喂饲正常大鼠和高脂膳食喂养形成的高脂血症大鼠，连续4周，测定血脂、肝脂及血浆和肝脏丙二醛(MDA)含量。结果表明：GLAME能显著降低正常大鼠和高脂血症大鼠血浆TC、TG、LDL—C含量和AI，升高HDL—C含量和HDL—C／TC，能降低正常大鼠和高脂血症大鼠血浆和肝脏MDA舍主及肝胆固醇含量，降低高脂血症大鼠肝指数(肝重/体重)，但对正常大鼠的肝指数无明显影响。 |
| English Summary: |
| The hyperlipemia model was established by feeding the rats with high fat diet. The hyperlipidemic rats were fed with the diet containing 0.25%,0.5%,1% gamma-linolenic acid methyl ester(GLAME), which was derived from Spirulina maxima for 4 weeks, then the plasma and liver lipid indexes were detected. The results showed that GLAME could significantly decrease levels of plasma total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C) , MDA,atherosclerosis index(AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol(HDL-C) in both normal and hyperlipidemic rats. GLAME decreased liver index(the ratio of liver weight and body weight) in hyperlipidemic rats, but had no significant effect in normal rats. |
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