| .扇贝多肽对小鼠非特异性免疫功能的调节作用[J].中国海洋药物,2006,25(5):38-40. |
| 扇贝多肽对小鼠非特异性免疫功能的调节作用 |
| Effect of PCF on the nonspecific immunity in mice |
| 投稿时间：2006-03-03 |
| DOI： |
| 中文关键词: 扇贝多肽,地塞米松,NK细胞,巨噬细胞 |
| English Keywords:polypeptides from chlamys farreri,dexamethasone,NK cells,macrophages |
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| 中文摘要: |
| 目的探讨扇贝多肽(PCF)对免疫低下小鼠非特异性免疫功能的调节作用。方法应用地塞米松(DEX)建立小鼠免疫抑制模型,采用乳酸脱氢酶(LDH)法和吞噬鸡红细胞法分别检测PCF腹腔注射对小鼠NK细胞杀伤活性和巨噬细胞吞噬功能的影响。结果实验证明PCF腹腔注射能够明显提高小鼠NK细胞杀伤活性(P<0.05),增强腹腔巨噬细胞吞噬功能(P<0.05)。结论PCF腹腔注射对DEX所致的免疫低下小鼠的非特异性免疫功能具有明显的保护作用。 |
| English Summary: |
| Objective To investigate the effects of PCF on the nonspecific immunity of immunosuppressed mice.Methods The immunosuppressed mice were established by injection of dexamethasone(DEX) intraperitoneally.Effects of PCF on the nonspecific immunity were studied by the LDH assay and the phagocytizing CRBC method.Results The NK cells cytotoxicity and the phagocytosis of macrophages were enhanced(P<0.05;P<0.05) in the DEX plus PCF treated mice compared to those in the DEX treated mice.Conclusion The experiment results indicated that PCF can obviously enhance the nonspecific immunity in immunosuppressed mice induced by DEX. |
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