| 康辉辉,马丽英,邵月华,等.佩特曲霉菌中1个新的色原酮类化合物△*[J].中国海洋药物,2017,36(5):23-27. |
| 佩特曲霉菌中1个新的色原酮类化合物△* |
| A new chromone derivative produced by Aspergillus petrakii |
| 投稿时间：2017-06-19 修订日期：2017-06-27 |
| DOI： |
| 中文关键词: 佩特曲霉菌 色原酮 盐碱地真菌 次生代谢产物 |
| English Keywords:Aspergillus petrakii chromones saline soil derived fungus secondary metabolites |
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| 中文摘要: |
| 目的 研究盐碱地来源的佩特曲霉菌在静置发酵条件下的次级代谢产物。方法 用正反相硅胶柱、Sephadex LH-20、高效液相等色谱技术对目标菌株的次生代谢产物进行分离纯化,经核磁共振谱、质谱、单晶X衍射等光谱方法和理化性质确定化合物的结构。结果 从佩特曲霉菌的静置发酵物中分离得到6个单体化合物,分别鉴定为：5-甲基-2-乙酰基-7-羟基色原酮 (1),2,5-二甲基-7-羟基色原酮 (2),avellanine A (3),avellanine B (4),(E)-N-[2-(4-羟基苯基)]乙烯基甲酰胺 (5),(Z)-N-[2-(4-羟基苯基)]乙烯基甲酰胺 (6)。结论 化合物1为新化合物,化合物2-6均为首次从佩特曲霉菌中获得。化合物1-6均没有明显的抗肿瘤活性。 |
| English Summary: |
| Objective To study the chemical constituents of the static fermentation broth of Aspergillus petrakii. Methods The secondary metabolites were isolated and purified by silica gel, ODS, Sephadex LH-20 column chromatography and semi-preparative HPLC. The structures of compounds were established by NMR, ESI-MS , X-ray data and physic-chemical properties. Results Six compounds were identified as 2-acetyl-7-hydroxy-5-methyl chromone (1), 7-hydroxy-2,5-dimethyl chromone (2), avellanine A (3), avellanine B (4), (E)-N-[2-(4-hydroxyphenyl)] ethenyl formamide (5), (Z)-N-[2-(4-hydroxyphenyl)] ethenyl formamide (6). Conclusion Compound 1 is a new chromone derivative, while compounds 2-6 are obtained from A. petrakii for the first time. Compounds 1-6 show no obvious cytotoxicity against A549 and HL-60 cell lines. |
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