| 徐启航,安法梁,李蕾,等.一株蓝藻来源真菌Aspergillus sp.的次生代谢产物研究[J].中国海洋药物,2019,38(1):28-32. |
| 一株蓝藻来源真菌Aspergillus sp.的次生代谢产物研究 |
| Studies on the Secondary Metabolites from Cyanobacteria-derived Fungus Aspergillus sp. |
| 投稿时间：2018-09-29 修订日期：2019-01-29 |
| DOI： |
| 中文关键词: 蓝藻来源真菌 次生代谢产物 曲霉 |
| English Keywords:cyanobacteria-derived fungus secondary metabolites Aspergillus sp. |
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| 中文摘要: |
| 目的 研究一株采自中国三亚蓝藻(Lyngbya majuscula)来源的真菌Aspergillus sp.的次生代谢产物的分离纯化、结构鉴定及其生物活性评价。方法 利用硅胶色谱、HPLC等色谱学分离方法对真菌Aspergillus sp.的次生代谢产物进行分离纯化,并结合NMR,MS等波谱学方法对分离得到的化合物进行结构鉴定；并采用CCK8法,用人肺癌细胞株A549和人乳腺癌细胞株MCF7评价了这6个化合物的细胞毒活性。结果 从真菌Aspergillus sp.的代谢产物中分离得到6个化合物：methyl asterric acid (1),methyl 3-chloroasterric acid (2),methyl 3,5-dichloroasterric acid (3),dihydrogeodin (4),benzomalvin B (5) 和benzomalvin E (6)。结论 化合物5和6为首次从Aspergillus属真菌中获得,化合物 1-6在40 μM浓度下没有显著的细胞毒活性。 |
| English Summary: |
| Objective To study the secondary metabolites of a cyanobacteria-derived fungus Aspergillus sp. collected from the South China Sea. Methods The chemical constituents of Aspergillus sp. were isolated and purified by silica gel chromatography, HPLC and other methods. The structures of isolated compounds were identified by NMR and MS data. In addition, their cytotoxic activities were evaluated by CCK8 methods on human lung cancer cell line A549 and human breast cancer cell line MCF7. Results Six compounds were isolated from the cyanobacteria-derived fungus Aspergillus sp. and identified as methyl asterric-acid (1), methyl 3-chloroasterric acid (2), methyl 3,5-dichloroasterric acid (3), dihydrogeodin (4), benzomalvin B (5), and benzomalvin E (6). Conclusion Compounds 5-6 were firstly isolated from the fungus Aspergillus sp.. The compounds 1-6 showed no significant activity at 40 μM concentration. |
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