| .螺旋藻藻蓝蛋白对癌激光疗法增敏作用的实验研究[J].中国海洋药物,1995,14(1):15-18. |
| 螺旋藻藻蓝蛋白对癌激光疗法增敏作用的实验研究 |
| THE EXPERIMENTAL STUDY OF APPLICATION OF PHYCOCYANIN IN CANCER ALSER THERAPY |
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| DOI： |
| 中文关键词: 藻蓝蛋白 钝顶螺旋藻 激光疗法 大肠肿瘤 |
| English Keywords:phycocyanin,Spirulina platensis,human colon cancer cell line HR8348,mouse transplanted tumour,cancer laser therapy |
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| 中文摘要: |
| 用藻蓝蛋白处理２种癌细胞作体风个激光治癌试验。人大肠癌细胞株ＨＲ８３４８培养后分别用１００μｇ和５０μｇ的藻蓝蛋白处理，经光波为６３０ｎｍ的铜激光辐照１２Ｊ／ｃｍ＾２，用ＭＴＴ法检培养癌细胞存活率分别为２２．２％，３７．６％和８９．７％，显示良好的剂量效应。 |
| English Summary: |
| The application of phycocyanin in laser therapy of two cancer cell lines was conducted both in vivo and in vitro. Human colon cancer HR8348 cells were incubated with 100ug,50ug and 25ug of phycocyanin,and subsequently irradiated with copper vaporu laser with density of 12 J/cm2 and wavelength of 630 nm. The survival rate thus assessed with MTT assay were 22. 2%, 37. 6% and 89. 7%, exhibiting a linear dose response. Mice transplanted with S180 cells were either injected with 2 mg or orally taken with 20 mg of phycocyanin. After irradiated with copper vapour laser for 15 days,the effective curing rates were 58% and 53% with statistical significance compared with their controls ( P =0. 007). Both in vivo and in vitro test proved that phycocyanin was of photo sensitivity, no toxicity and no adverse effect. Therefore,phycocyanin may be explored as a refined photo sensitizer used for cancer laser therapy. |
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