| .JunceellinA水解产物的制备及其对肺癌A—549细胞的活性[J].中国海洋药物,1995,14(3):1-4. |
| JunceellinA水解产物的制备及其对肺癌A—549细胞的活性 |
| THE HYDROLYTIC PRODUCTS OF JUNCEELLIN A FROM JUNCEELLA SQUAMATA AND THEIR ACTIVITIES TO INHIBIT THE LUNG CANCER A-549 CELLS |
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| DOI： |
| 中文关键词: JunceellinA 水解产物 肺肿瘤 A－549细胞 |
| English Keywords:Junceellin A,hydrolytic product,anti-lung-cancer activity |
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| 中文摘要: |
| 从南海鳞灯芯珊瑚Ｊｕｎｃｅｌｌａｓｑｕａｍａｔａ分离出的ＪｕｎｃｅｅｌｌｉｎＡ（ＪＡ）分界用Ｋ２ＣＯ３和２ｍｏｌ／ＬＨＣｌ水解得到二羟基产物（ＪＡ）和四羟基产物（ＪＡ２），初步药理试验显示，ＪＡ１和ＪＡ２浓度在３０～５０μｇ／ｍＬ，具有抑制肺癌Ａ－５４９细胞生长的活性，ＪＡ２的效应比ＪＡ１强，ＪＡ２对正常人细胞的生长无影响。 |
| English Summary: |
| Junceellin A (JA) from Junceella squamata was hydrolyzed in K2CO3 and 2 mol/L MCI and gave dihydroxy product (JA1),and tetrahydroxy product (JA2) respectively. The preliminary bioassay showed that JA1 and JA2 in 30~50 ug/mL had activities to inhibit the growth of lung cancer A-549 ceils. The effect of JAi was stronger than that of JA1. JA2 didn't affect the growth of human normal cells (HF). |
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