.褐藻糖胶的免疫调节作用[J].中国海洋药物,1995,14(3):9-13. |
褐藻糖胶的免疫调节作用 |
AN EXPERIMENTAL STUDY ON IMMUNOREGULATORY EFFECT OF FUCOIDAN |
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DOI: |
中文关键词: 褐藻糖胶 免疫调节 |
English Keywords:Fucoidan,Immunoregulatory effect |
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中文摘要: |
观察了从海带中提取的褐藻糖胶对小鼠免疫功能的影响,褐藻糖胶在体外可诱导白细胞介素1(IL-1)和丙型干扰素(IFN-γ)产生;体内给药可增强T细胞,B细胞,巨噬细胞(M)和自然杀伤细胞(NK细胞)功能,促进对绵羊红细胞(SRBC)的初次抗体应答。 |
English Summary: |
Funcoidan (FCD) is a polysaccharide extracted from Laminaria japonica Aresh. When we injected FCD into mice subcutaneously for 9 days in our experiments, splenocyte proliferation induced by mitogen (Con A, PHA, LPS), IL - 1 production of peritoneal M?induced by Lps and IL - 2 production of splenocyte induced by Con A were promoted and the primary antibody response to SRBC of murine splenocyte was also promoted. FCD could directly stimulated murine splenocyte to produce IFN - 7. FCD, in vitro or in vivo ,could enhance NK activity. |
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