| .二十碳五烯酸抗拴作用的实验研究[J].中国海洋药物,1995,14(4):. |
| 二十碳五烯酸抗拴作用的实验研究 |
| EXPERIMENTAL STUDIES ON ANTITHROMBOSIS OF EICOSAPENTAENOIC ACID |
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| DOI： |
| 中文关键词: 二十碳五烯酸,抗血栓,血小板聚集,血栓素B_2,6-酮前列腺素F_(1α) |
| English Keywords:Eicosapentaenoic acid (EPA),thromboxane B2 (TXB2 ),6-ketp-PGF1a,antithrombosis,pialelet aggregation |
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| 中文摘要: |
| 对二十碳五烯酸(EPA)的抗栓作用及其机制进行了研究。结果表明,EPA在体内、体外均有明显抗栓作用,并能增强纤溶活力,缩短优球蛋白溶解时间,抑制花生四烯酸和胶原诱导的大鼠血小板聚集。放射免疫测定证明,EPA能降低小鼠血浆血拴素B_2(TXB_2)含量,提高6-酮前列腺素F_(1α)与TXB_2的比值。 |
| English Summary: |
| The effects of eicosapentaenoic acid (EPA) on experimental thrombosis and its mechanism were studied. The results showed that eicosapentaenoic acid had a significant antithrombolic effect both in vivo and in vitro . EPA also had a fibrinolytic activity and can shorten euglobulin lysis time. Our studies also showed that EPA can inhibit platelet aggregation in rats. The plasma concentration of 6-keto-PGF1a and TXB2 was measured by radioimmunoassay. The results showed that EPA can reduce the contents of TXB2 and raise 6-keto-PGF1a/TXB2 ratio. |
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