| .DHA改善大鼠记忆作用的实验研究[J].中国海洋药物,1996,15(4):22-24. |
| DHA改善大鼠记忆作用的实验研究 |
| THE EFFECTS OF DHA ON RATS MEMORY |
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| DOI： |
| 中文关键词: 鱼油 DHA 二十二碳六烯酸 记忆 实验研究 |
| English Keywords:fish oil,docosahexaenoic acid (DHA),memory |
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| 摘要点击次数: 2824 |
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| 中文摘要: |
| 通过训练大鼠在迷宫中的主动性条件回避反应学习记忆能力，观察了富含ＤＮＡ的鱼油对大鼠记忆的影响，用ＤＨＡ１．０ｇ／ｋｇ、２００ｍｇ／ｋｇ，４０ｍｇ／ｋｇ分别给大鼠连续灌胃２０ｄ，每日２次，结果表明，ＤＮＡ可减少对在鼠达标前所需的反应次数，提高正确反应率，改善记忆作用，并具有一定的量效关系，２００ｍｇ／ｋｇ剂量的ＤＨＡ能拮抗东莨菪所致的记忆障碍，提高记忆获得能力。 |
| English Summary: |
| w-3 polyunsaturated fatty acids, particularly docosahexaenoic acid (DHA) , are essential components for the development of human brain. A fish oil product enriched with DHA (51. 65%) was used to conduct a preliminary memory study with rats employing the active avoidance test. Three doses of DHA, 1. 0 g/kg, 200 mg/kg and 40 mg/kg, were administered orally to the rats twice daily for 20 days. The results showed that there was a positive correlation between the effects on memory ability and DHA adiministration, and the effects were dose responsive. The results also showed that DHA, at 200 mg/kg, could antagonize dysmnesia caused by scopolamine and had hypermnesia effect. |
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