| .鲨骨精抗黑色素瘤肺转移及调节免疫功能的研究[J].中国海洋药物,1998,17(2):37-40. |
| 鲨骨精抗黑色素瘤肺转移及调节免疫功能的研究 |
| THE EFFECT OF SHARK CARTILAGE ACTIVE EXTRACT (SCAE) ON THE LUNG METASTASIS AND IMMUNE FUNCTION IN MICE |
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| 中文关键词: 黑色素瘤 肺转移 肺脏 机体免疫功能 调节免疫 B16细胞 有核细胞 抑制率 脾脏 活性 |
| English Keywords:shark cartilage,tumor metastasis,immune fuction |
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| 中文摘要: |
| 鲨骨精(shark cartilage active extract．SCAE)是鲨鱼软骨提取物。本项研究评价其抗黑色素瘤B16肺脏转移及调节机体免疫功能的作用。小鼠口服SACE后d7，经尾静脉注射黑色素细胞瘤B16细胞悬液；3w后计数黑色素瘤肺脏转移结节，测定脾细胞的免症功能。结果表明，SCAE能抑制黑色素瘤B16肺转移，抑制率为33%能提高脾脏有核细胞总数、淋巴细胞增殖能力和LAK细胞活性。证实了SCAE能抑制黑色素癌转移及提高机体免疫功能。 |
| English Summary: |
| The effect of shark cartilage active extract (SCAE) on the lung metastasis and the immune function were studied in C57 mice with oral administration. The formation of pulmonary metastasis (B16 melanoma)was significantly inhibited, with an inhibitory rate of 33. 1%. The proliferation rate of spleen cells to ConA was obviously increased,the increased rate being as high as that of the normal. The cytotoxicity of LAK cells is also increased,but lower than that of the mormal. |
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