| .两种贝类核糖核酸的提取及其抗肿瘤活性的初步研究[J].中国海洋药物,1998,17(2):46-48. |
| 两种贝类核糖核酸的提取及其抗肿瘤活性的初步研究 |
| PRELIMINARY STUDIES ON THE EXTRACTION AND THE ANTITUMOR ACTIVITY OF RIBONUCLEIC ACID ( RNA ) FROM PINCTADA MARTENSII AND PINNA PECTINATA |
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| DOI： |
| 中文关键词: 抗肿瘤活性 RNA 核糖核酸 抑瘤率 初步研究 小鼠 观察 贝类 蛋白 碱性条件 |
| English Keywords:ribonucleic acid (RNA),Pinctada martensii,Pinna pectinata,antitumor activity |
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| 中文摘要: |
| 报道了在微碱性条件下，用苯酚扣氯仿等将蛋白扣脂肪除去，从马氏珠母贝[Pincfnda martensii (Dunker)]和栉江瑶(Pinna pectinata Linnaeus)中提取核糖核酸(RNA)的方法，并用所提取的RNA对荷S-180肿瘤的小鼠进行了抗肿瘤活性的初步观察。结果表明、两种贝类中的RNA有一定的抗肿瘤活性，抑瘤率分别为41．2%～45.1%和38．8％。 |
| English Summary: |
| Ribonucleic acid (RNA) was extracted from Pinctada martensii and Pinna pectinata at a weak alkaline environment by removing the protein and fat through adding phenol and chloroform. It also reported the antitumor activity of RNA on mice with sarcoma-180 and has discovered that RNA has an obvious effect of inhibiting the tumor growth in mice with the inhibition rates being ranged from 41. 2% to 45. l%,and 38. 8% , respectively. |
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