| .云南产钝顶螺旋藻多糖对D-半乳糖所致衰老小鼠的作用[J].中国海洋药物,1998,17(3):. |
| 云南产钝顶螺旋藻多糖对D-半乳糖所致衰老小鼠的作用 |
| EFFCT OF POLYSACCHARIDE FROM THE SPIRULINA PLATENSIS CULTIVATED IN CHINA''''S YUNNAN PROVINCE ON THE D-GALACTOSE AGING MODEL MICE |
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| DOI： |
| 中文关键词: 螺旋藻多糖(PSP),D-半乳糖衰老模型,抗衰老 |
| English Keywords:polysaccharide of Spirulina platensis (PSP),D-galactose induced aging model,anti-aging |
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| 中文摘要: |
| 雌性NIH小鼠每天颈背sc D-半乳糖80mg/kg,连续42d,造成亚急性衰老模型。在注射D-半乳糖的同时每天分别ig钝顶螺旋藻多糖(PSP)200mg/kg、100mg/kg,能显著降低小鼠心、肝脑组织MDA含量,明显促进红细胞、肝及脑SOD活性,使全血及肝GSH-Px活性与GSH含量恢复至正常水平,同时使肝、脑MAO-B活性显著降低,皮肤羟脯氨酸含量显著回升。提示PSP对D-半乳糖所致衰老小鼠有明显的改善作用。 |
| English Summary: |
| With the dose of D-galactose 80mg/kg by sc administration to the female NIH mice for 6 weeks,the sub-acute aging model was established. In order to observe the effect of the polysaccharide (PSP) on anti-aging, the mice were received PSP 200mg/kg^ 100mg/kg respectively by ig administration at the same time of injection D-galactose. It was found that PSP could remarkably antagonise the effect of D-galactose on the mice. The results showed that PSP could significantly(1)decrease the content of MDA in heart,liver and brain of the mice;(2)increase the SOD activity of RBCJiver and brain in the mice;(3)increase the GSH-Px activity and GSH content of the blood and liver of the mice; (4)inhibit the MAO-B activity of liver and brain in the mice;(5)increase the hydroxyproline content of dermal tissue in aging model mice. In short,it is suggested that PSP could obviously improve the aging effect of D-galactose on the mice. |
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