| .一种增强神经元钙电流的新型织锦芋螺毒素[J].中国海洋药物,2003,22(2):5-10. |
| 一种增强神经元钙电流的新型织锦芋螺毒素 |
| A new conotoxin from conus textile enhancing Ca2+ current of neurons |
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| DOI： |
| 中文关键词: 神经元钙电流 新型织锦芋螺毒素 生物活性 电生理 织锦芋螺 |
| English Keywords:conus textile,conotoxin,isolation,purification,biological activity,electrophysiology |
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| 中文摘要: |
| 目的：从中国南海织锦芋螺中分离生物活性强、电生理效应特异、新的芋螺毒素。方法：毒素分离纯化，生物活性测定，氨基酸测序，电生理效应研究。结果：分离到一种新的织锦芋螺毒素Tx7，序列为GCSS—VCNSHTDCVTHCICTFRGCGAVN，能引起小鼠疫挛，并能增强海马神经元钙电流和提高兴奋性突触后电流的发放频率。结论：Tx7具有较高的潜在应用价值。 |
| English Summary: |
| Objective Isolating new conotoxins with high biological activity and special electro-physiological effect from Conus textile in the South China Sea. Methods Isolation and purification of conotoxins, biological activity determination, amino acids analysis and electrophysi-ological studies. Results A new conotoxin named Tx7 was obtained from Conus textile. Its sequence was GCSSVCNSHTDCVTHCICTFRGCGAVN. Tx7 causes mouse spastic as well as enhances Ca2+ current and increase frequency of EPSC (excitatory postsynaptic current) of hippocampal neurons. Conclution Tx7 has high potential application value. |
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