| .聚乙烯醇改性医用壳聚糖微球的制备及其血脂吸附实验[J].中国海洋药物,2003,22(3):25-27,32. |
| 聚乙烯醇改性医用壳聚糖微球的制备及其血脂吸附实验 |
| Preparation of medical chitosan microspheres improved with polyvinyl alcohol and its adsorption test of blood lipids |
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| 中文关键词: 聚乙烯醇 壳聚糖 医用微球 制备 血脂吸附 低密度脂蛋白 |
| English Keywords:chitosan,polyvinyl alcohol(PVA),medical microsphere,adsorption,LDL |
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| 中文摘要: |
| 目的：制备性能优良的医用壳聚糖微球，用于吸附血脂。方法：以壳聚糖为原料，液体石蜡为悬浮介质，加入适量的交联剂戊二醛和少量的改性剂聚乙烯醇(PVA)，采用悬浮交联工艺，制备壳聚糖微球，采用动态法进行血脂吸附。结果：加入少量PVA制成的壳聚糖微球更有利于吸附血脂中低密度脂蛋白(LDL)、总胆固醇(TC)、甘油三酯(TG)。结论：加入少量改性剂PVA的壳聚糖微球有望成为性能优良的、能选择性吸附血脂的医用微球。 |
| English Summary: |
| Objective To prepare medical chitosan microspheres used in blood lipid adsorption. Methods Medical chitosan microspheres were prepared by suspending chitosan in liquid paraffin, adding proportional glutaraldehyde as crosslinking agent and a small amount of polyvinyl alcohol(PVA) to improve its flexibility. The blood lipid adsorption v/ere studied in a dynamic way. Results The medical chitosan microspheres containing a small amount of PVA were more effective in decreasing the contents of cholesterol(CH) , triglyceride(TG) , LDL in human serum. Conclusion The chitosan microspheres obtained by adding a small amount of PVA could be used as a desirable medical microsphere in the adsorption of blood lipids. |
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