| .低分子甲壳铵在小鼠体内吸收与分布的研究[J].中国海洋药物,2005,24(3):15-17. |
| 低分子甲壳铵在小鼠体内吸收与分布的研究 |
| Studies on the absorption and distribution of low molecular N-trimethyl chitosan chloride in mice |
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| DOI： |
| 中文关键词: 低分子甲壳铵 体内吸收 体内分布 |
| English Keywords:low molecular N-trimethyl chitosan chloride,body absorption,body distribution |
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| 中文摘要: |
| 目的研究低分子甲壳铵在小鼠体内的吸收及其在组织中的分布。方法采用氚标记法．测定低分子甲壳铵灌胃后的血药浓度，药动学参数采用DAS ver1．0程序计算，观察其在小鼠体内的组织分布。结果低分子甲壳铵药动学符合二室模型，在肾、肝、脾中分布较高．其在肿瘤组织中的分布显著高于正常小鼠同一部位的肌肉组织。结论低分子甲壳铵口服可吸收，并易于与肿瘤结合．有望开发成为一种口服抗肿瘤药。 |
| English Summary: |
| Objective To study the absorption and distribution of low molecular N-trimethyl chitosan chloride in mice.Methods Using tritium marking method to determine the concentrations of low molecular N-trimethyl chitosan chloride in serum after oral administration.Its pharmacokinetics were analysed by DAS ver1.0 program and the distributions in tissues were examined. Results The pharmacokinetics of low molecular N-trimethyl chitosan chloride were consistent with two-compartment model.The radioactive concentrations in liver,kidney,lung and spleen were higher than those in other tissues.And the radioactive concentration in cancer was higher. Conclusion Low molecular N-trimethyl chitosan chloride could be absorbed after oral administration.It was easily conjugate with cancer surface and could be developed as an anticancer drug for oral use in the future. |
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