| .扇贝多肽对小鼠免疫功能调节的研究[J].中国海洋药物,2005,24(3):18-21. |
| 扇贝多肽对小鼠免疫功能调节的研究 |
| Immunomodulation of polypeptides from Chlamys farreri (PCF) in mice |
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| DOI： |
| 中文关键词: 扇贝多肽 地塞米松 胸腺 脾脏 淋巴细胞 |
| English Keywords:polypeptides from Chlamys farreri(PCF),dexamethasone,thymus,spleen,lymphocyte |
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| 中文摘要: |
| 目的探讨扇贝多肽(PCF)对免疫低下小鼠免疫功能的调节作用。方法应用地塞米松(DEX)建立小鼠免疫抑制模型，通过形态学、细胞功能学和流式细胞分析等方法研究PCF腹腔注射对机体免疫功能的影响。结果：PCF腹腔注射能够明显改善DEX所致的免疫低下反应．脾脏白髓组织明显增大，外周血T淋巴细胞数量增多和脾淋巴细胞对ConA诱导的转化能力明显提高。结论PCF腹腔注射对小鼠免疫功能具有一定的正向调节作用，可能主要是通过影响外周成熟的免疫细胞而发挥作用。 |
| English Summary: |
| Objective To investigate the immunomodulation of PCF on the immunosuppressed mice. Methods The immunosuppressed model was established by injection of dexamethasone (DEX) intraperitoneally. Effects of PCF on the immunity were studied by the observation of morphology of immune organ, the analysis of T lymphocytes subsets and the measurement of lymphoproliferative ability. Results PCF could markedly improve the low immunoreaction of immunosuppressed mice caused by DEX. It was showed that the white pulp of spleen was enlarged, the quantity of T lymphocytes of the peripheral blood was increased and the response of lymphoproliferation to ConA was enhanced in the test group compared to those in the model group. Conclusion PCF had the abilities to up-regulate the immunity in vivo,which may be due to its influences on the peripheral mature immunocytes. |
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