| .一种新型海洋纤溶酶体外抗凝与溶栓作用研究[J].中国海洋药物,2006,25(4):37-42. |
| 一种新型海洋纤溶酶体外抗凝与溶栓作用研究 |
| Study on anticoagulant and thrombolytic effects of a novel marine fibrinolytic enzyme in vitro |
| 投稿时间：2006-01-01 |
| DOI： |
| 中文关键词: 海洋纤溶酶,抗凝血活性,溶栓作用 |
| English Keywords:marine fibrinolytic enzyme,anticoagulant activity,thrombolytic effect |
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| 中文摘要: |
| 目的对本实验室制备的一种相对低分子质量新型海洋纤溶酶的体外抗凝和溶栓作用进行初步评价,为进一步的动物实验研究打下基础。方法以pH7.4的生理盐水作阴性对照,以蚓激酶作阳性对照,在体外研究新型海洋纤溶酶对Wistar大鼠和家兔新鲜血液的抗凝集和血栓溶解作用。结果该新型海洋动物纤溶酶具有显著的血栓溶解作用,并具有一定的抗凝血效果,从血栓中释放的血细胞形态较使用蚓激酶优。结论该新型海洋纤溶酶具有潜在的应用价值。 |
| English Summary: |
| Objective To estimate the anticoagulant and thrombolytic effects of a novel fibrinolytic enzyme with a low molecular weight for further carrying on animal test and clinic research.Methods Using pH7.4,0.9 % NaCl as negative control and lumbrukinase as positive control,the anticoagulant and thrombolytic effects of the novel marine fibrinolytic enzyme were investigated in vitro with fresh blood from wistar rat and rabbit,respectively.Results The results showed that there were apparent anticoagulant effect as well as thrombolytic effects in the self-made marine fibrinolytic enzyme,and the status of the released blood cells from thrombus using this enzyme was also better than that of using lumbrukinase.Conclusion The novel self-made fibrinolytic enzyme is a potent thrombolytic agent. |
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