| .羧甲基壳聚糖钙对染铅小鼠治疗性排铅作用的研究[J].中国海洋药物,2007,26(1):28-30. |
| 羧甲基壳聚糖钙对染铅小鼠治疗性排铅作用的研究 |
| Study on lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice |
| 修订日期：2006-08-10 |
| DOI： |
| 中文关键词: 羧甲基壳聚糖钙 铅中毒 抗氧化 |
| English Keywords:carboxymethyl chitosan calcium(CCC),lead poisoning,antioxidation |
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| 中文摘要: |
| 目的观察羧甲基壳聚糖钙对染铅小鼠排铅作用及其抗氧化能力的影响。方法小鼠随机分组，饮用醋酸铅水溶液建立小鼠铅中毒模型。然后灌胃受试物，连续30d后，采血，取肝脏、全脑、股骨，用原子吸收分光光度计测定其铅、钙含量。同时测定小鼠肝组织中的抗氧化指标。结果羧甲基壳聚糖钙能显著降低染铅小鼠血液、全脑、肝脏、股骨铅含量，降低染铅小鼠肝脏中MDA水平，显著升高SOD、GSH—Px、T—AOC活性，增加股骨钙含量。结论羧甲基壳聚糖钙能显著促进染铅小鼠排铅，增强抗氧化能力，还具有一定的补钙功效． |
| English Summary: |
| Objective To observe the effect of carboxymethyl chitosan calcium(CCC) on the concentration of lead,calcium,and liver antioxidative capacity in lead poisoned mice.Methods mice were randomly divided into 6 groups.Three test groups were treated with CCC at three doses.The lead poisoned mice model was established by giving water containing lead acetate,and then CCC was administered to mice once a day.After 30 days,the mice were killed and the content of lead in blood,liver,brain and femur were determined by atomic absorption spectrophotometer,and antioxidative capacity in liver was measured using assay kit.Results CCC could reduce the contents of lead in blood,brain,liver and femur significantly,decrease the level of maleicdialdehyde(MDA),increase activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and total antioxidative capacity(T-AOC) in liver markedly. Conclusion CCC can promote the excretion of lead,increase the content of calcium in femur and antioxidative capacity in lead poisened mice. |
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