| 郭琼,彭光天,刘炳新,等.南海珊瑚内生细菌Brevibacterium sp.中的环二肽成分研究II[J].中国海洋药物,2014,33(3):. |
| 南海珊瑚内生细菌Brevibacterium sp.中的环二肽成分研究II |
| Research on cyclo-dipeptides from the Coral-derived Bacteria Brevibacterium sp. of South China Sea (II) |
| 投稿时间：2013-12-17 修订日期：2014-01-23 |
| DOI： |
| 中文关键词: 珊瑚内生细菌 Brevibacterium sp. 环二肽 结构解析 |
| English Keywords:Coral-derived bacteria Brevibacterium sp cyclo-dipeptides identification of structures |
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| 中文摘要: |
| 目的 对南海珊瑚内生细菌Brevibacterium sp.化学成分进行研究。方法 采用硅胶柱色谱,Sephadex LH-20凝胶柱色谱,高效液相柱层析等分离手段对珊瑚内生细菌Brevibacterium sp.发酵液的乙酸乙酯提取物进行分离纯化,采用NMR、质谱(MS)等现代波谱解析手段,并与文献对照,鉴定化合物结构。结果 分离得到12个已知的环二肽类化合物,其结构分别为环(色-苏)二肽(1)、环(4-羟基-脯氨酸-酪)二肽(2)、环(亮-酪)二肽(3)、环(苯丙-丙)二肽(4)、环(异亮-甘)二肽(5)、环(亮-甘)二肽(6)、环(亮-脯)二肽(7)、环(亮-丙)二肽(8)、环(异亮-丙)二肽(9)、环(亮-苏)二肽(10)、环(异亮-缬)二肽(11)、环(异亮-异亮)二肽(12)。结论 所有化合物均首次从Brevibacterium属中分离得到。 |
| English Summary: |
| Objective Research on cyclo-dipeptides from from the Coral-derived Bacteria Brevibacterium sp. L-4 of South China Sea. Methods Compounds were isolated by all kinds of column chromatography, such as silica gel, Sephdex LH-20, ODS, and purified by HPLC. Their structures were identified by spectroscopic analysis (NMR, MS, GC-MS, and so on), chemical and physical methods, and comparing with references. Results Twelve compounds were isolated from the fermentation broth of coral-derived bacteria L-4 in South China Sea, and their structures were determined as cyclo- (Trp-Thr) (1), cyclo- (4- OH-Pro-Tyr) (4), cyclo- (Leu-Tyr) (3), cyclo-(Ala-Tyr) (4), cyclo- (Leu- Gly) (6), cyclo- (Ile-Pro) (7), cyclo- (Leu-Ala) (8), cyclo- (Ile-Ala) (9), cyclo- (Ile-Thr) (10), cyclo- (Ile-Val) (11), cyclo- (Ile-Ile) (12). Conclusion All compounds were cyclo-dipeptides and first obtained from the marine coral-derived bacterium Brevibacterium sp.. |
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