| 陈正波,万升标,朱伟明.海洋来源的天然α-糖苷酶抑制剂研究进展[J].中国海洋药物,2016,35(3):105-111. |
| 海洋来源的天然α-糖苷酶抑制剂研究进展 |
| Research progress of natural α-glucosidase inhibitors from marine organisms |
| 投稿时间：2015-05-13 修订日期：2015-05-26 |
| DOI： |
| 中文关键词: 糖尿病 α-糖苷酶抑制剂 海洋天然产物 |
| English Keywords:diabetes mellitus α-glucosidase inhibitor marine natural products |
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| 中文摘要: |
| α-葡萄糖苷酶抑制剂(AGIs)是一类以延缓肠道糖类吸收而达到治疗糖尿病的口服降糖药物。从海洋天然产物宝库中寻找新型α-葡萄糖苷酶抑制剂对发现高效低毒的治疗II型糖尿病(T2DM)药物具有重要意义。本文综述了45个海洋动物、植物以及微生物来源的天然α-葡萄糖苷酶抑制剂的结构、活性及其生物来源,还简要探讨了其构效关系,即酚羟基、卤素和不饱和双键、叁键的存在有助于增强化合物的α-葡萄糖苷酶抑制活性。 |
| English Summary: |
| The α-glucosidase inhibitors (AGIs) are a kind of oral anti-diabetic medications that can retard the absorption of intestinal carbohydrate. It is important for the treatment of type II diabetes to find novel α-glucosidase inhibitors derived from marine natural source that with high efficiency and low toxicity. This paper introduced 45 natural α-glucosidase inhibitors from marine animals, plants and microorganisms, including their structures, bioactivities and the biological source. In addition, analysis of simple structure-activity relationship revealed that the presence of phenolic hydroxyl groups, halogens, and unsaturated double or triple bonds contributed to the enhancement of compounds’ inhibitions on α-glucosidase. |
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