| 袁莉,汤华,庄春林,等.海洋卤代吲哚生物碱的生物活性研究进展[J].中国海洋药物,2016,35(3):93-104. |
| 海洋卤代吲哚生物碱的生物活性研究进展 |
| Progress in the biological activity of marine halogenated indole alkaloids |
| 投稿时间：2015-06-11 修订日期：2015-07-08 |
| DOI： |
| 中文关键词: 海洋 卤代吲哚生物碱 生物活性 化学结构 |
| English Keywords:marine halogenated indole alkaloid bioactivity structure |
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| 中文摘要: |
| 吲哚生物碱是一类重要的海洋次生代谢产物,主要包括单吲哚、双吲哚和三吲哚结构衍生物。卤素取代是海洋吲哚生物碱的一个重要特点,其取代位置大多在吲哚环的5位或者6位,这些化合物显示抗肿瘤、抗微生物、抗组胺、5-HT抑制等多种生物活性,具有潜在药用价值。本文对海洋来源卤代吲哚生物碱的主要生物活性、来源和结构进行了综述,共涉及81个化合物,涵盖了从1978年到2014年的48篇文献。 |
| English Summary: |
| Indole alkaloid from marine sources is an interesting cluster of secondary metabolites that are mainly sorted into mono-, bis-, and tris-indole derivatives. These metabolites are characterized by halogenation substitution mainly occurred at C-5 or C-6 of indole subunit. Halogenated indole alkaloids demonstrate a wide spectrum of biological activities, e.g. anti-tumor, anti-microbial, anti-histamine, and serotonin inhibitory activities, displaying a potential pharmaceutical value. This paper gives a brief review on the main bioactivities, origin and chemistry of marine halogenated indole alkaloids, involving 81 compounds and 48 references from 1978 to 2014. |
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