| 王翠芳;管菲菲;杜思颖;魏美燕;王长云;邵长伦;.花柳珊瑚来源的真菌Arthrinium sp. 中的两个多羟基氧杂蒽酮类化合物及其抗病毒活性研究（英文）[J].中国海洋药物,2016,35(4):30-34. |
| 花柳珊瑚来源的真菌Arthrinium sp. 中的两个多羟基氧杂蒽酮类化合物及其抗病毒活性研究（英文） |
| Two polyhydroxy xanthones and their antiviral activity from gorgonian coral-derived fungus Arthrinium sp. |
| 投稿时间：2015-08-25 修订日期：2015-09-07 |
| DOI：10.13400/j.cnki.cjmd.2016.04.006 |
| 中文关键词: 花柳珊瑚，Arthrinium sp.，多羟基氧杂蒽酮，抗病毒活性，X-ray |
| English Keywords:gorgonian coral, Arthrinium sp., polyhydroxy xanthone, antiviral activity, X-ray. |
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| 摘 要：目的 研究从花柳珊瑚共附生真菌Arthrinium sp.分离得到的1-甲基-2,3,6,8-四羟基氧杂蒽酮（1）和1-甲基-2,3,4,6,8-五羟基氧杂蒽酮（2）的化学结构及其抗细菌和抗病毒活性。方法 利用现代波谱解析方法和X-ray单晶衍射技术，对化合物1和2的化学结构进行研究；利用抗细菌和抗病毒活性模型对其生物活性进行评价。结果 化合物1的结构首次通过单晶数据进一步确定；体外化合物1显示抗病毒活性，化合物1的IC50值为27.40 μM，强于阳性药利巴韦林的抗HSV活性(IC50 = 313.00 μM)。结论 化合物1的单晶数据、以及活性数据对今后系统研究氧杂蒽酮类化合物具有参考价值。 |
| English Summary: |
| Abstract: Objective To study the chemical structure and antibacterial and antiviral activity of 2,3,6,8-tetrahydroxy-1-methylxanthone (1) and 2,3,4,6,8-pentahydroxy-1-methylxanthone (2) isolated from a gorgonian coral-derived fungus. Methods The chemical structure of 1 and 2 were studied by using the modern spectrum analysis methods and X-ray crystallographic techniques. The biological activities including antimicrobial activity and antiviral activity were evaluated by using their evaluation models. Results Compound 1 was further confirmed by X-ray single-crystal diffraction analysis for the first time. Compound 1 showed significant anti-HSV activity in vitro with an IC50 value of 27.40 μM, which was stronger than that of the positive control ribavirin (IC50 = 313.00 μM). Conclusion The data of single-crystal, and bioactivity possessed reference value for the systematic?study of xanthones and their analogues in the future. |
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