| 陈全,王慧,石杰,等.甲壳素温敏水凝胶止血作用的研究[J].中国海洋药物,2017,36(1):71-75. |
| 甲壳素温敏水凝胶止血作用的研究 |
| Study on hemostatic function of a chitin thermo-sensitive hydrogel |
| 投稿时间：2016-03-26 修订日期：2016-04-01 |
| DOI： |
| 中文关键词: 甲壳素 温敏水凝胶 止血 |
| English Keywords:chitin thermo-sensitive hydrogel hemostasis |
| Fund Project: |
|
| 摘要点击次数: 5602 |
| 全文下载次数: 1334 |
| 中文摘要: |
| 目的 评价甲壳素温敏水凝胶的止血作用。方法 制作大鼠肝脏损伤出血模型,分为空白对照组、阳性对照组、实验组,空白对照组肝脏出血创面不使用止血材料,阳性对照组、实验组肝脏出血创面分别使用纤维蛋白粘合剂和甲壳素温敏水凝胶止血,记录出血时间和出血量,于术后测定血清中TGF-β1和IL-6的含量,观察肝脏愈合情况,对损伤肝脏进行组织学观察。结果 在手术中使用甲壳素温敏水凝胶能够快速止血,大鼠术后血清中TGF-β1和IL-6含量适中,在愈合过程中炎症反应轻。 |
| English Summary: |
| Objective To evaluate the hemostatic function of a chitin thermo-sensitive hydrogel. Methods The solution of thermo-sensitive chitin was injected on the surface of rats bleeding liver, both of bleeding time and blood loss were recorded. Fibrin glue was used as positive control. None of hemostatic agents were taken in blank control. Gross observation and histological analysis were taken to evaluate the condition of liver healing, and concentration of TGF-β1 and IL-6 were determined by Elisa assay kit in postoperation. Results Quick hemostasis could be achieved by using the chitin thermo-sensitive hydrogel in surgery, modest concentration of TGF-β1 and IL-6 were determined, and slight inflammation was observed after operation. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|