| 李涛,王斌,李平林,等.西沙海绵Agelas aff. Nemoechinata化学成分研究△[J].中国海洋药物,2017,36(2):22-26. |
| 西沙海绵Agelas aff. Nemoechinata化学成分研究△ |
| Study on chemical constituents of Xisha sponge Agelas aff. Nemoechinata |
| 投稿时间：2016-04-16 修订日期：2016-05-08 |
| DOI： |
| 中文关键词: 海绵 化学成分 结构鉴定 |
| English Keywords:sponge chemical constituents structural identification |
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| 中文摘要: |
| 目的 研究中国西沙海绵Agelas aff. Nemoechinata 二氯甲烷/甲醇部分的化学成分。方法 运用薄层色谱、硅胶柱色谱、Sephadex LH-20凝胶柱色谱、MPLC、HPLC等分离方法对该海绵化学成分进行分离纯化；利用核磁共振、质谱等结构鉴定技术,并结合文献,鉴定化合物的结构。结果 从海绵甲醇粗提物的二氯甲烷/甲醇部分分离鉴定了7个化合物：agelasine B (1)、2-oxo-agelasine B (2)、2’-oxo-agelasidine C (3)、2-甲酸吡咯负离子 (4)、2-甲酰胺吡咯 (5)、9-甲基腺嘌呤 (6)和尿嘧啶 (7)。结论 化合物1、2、3、4和6均为首次从该种分离得到。 |
| English Summary: |
| Objective To study the chemical constituents of the sponge Agelas aff. Nemoechinata. Methods The compounds were isolated by TLC, silica gel, Sephadex LH-20, MPLC and HPLC methods, and their structures were determined by spectroscopic analysis including NMR and MS, and comparison with the data of literatures. Results From the Dichloromethane/Methanol Part of A. aff. Nemoechinata, seven compounds were isolated and identified as agelasine B (1), 2-oxo-agelasine B (2), 2’-oxo-agelasidine C (3), 1H-?Pyrrole-?2-?carboxylic acid ion(1-?) (4), 2-pyrrole-carboxamide (5), 9-Methyla-denine (6) and Uracil (7). Conclusion Compound 1, 2, 3, 4and 6 were isolated from this sponge for the first time. |
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