| 王嘉慧,王春华,王建荣,等.广西北海涠洲岛陵水山海绵Mycale lingshuiensis的化学成分研究[J].中国海洋药物,2017,36(5):28-32. |
| 广西北海涠洲岛陵水山海绵Mycale lingshuiensis的化学成分研究 |
| Studies on the chemical constitutions of sponge Mycale lingshuiensis from the North China Sea |
| 投稿时间：2017-01-18 修订日期：2017-03-14 |
| DOI： |
| 中文关键词: 陵水山海绵 含氮类化合物 单吲哚生物碱 |
| English Keywords:Mycale lingshuiensis nitrogenous compounds monoindole alkaloids |
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| 中文摘要: |
| 目的 对采自中国广西北海涠洲岛海域的陵水山海绵Mycale lingshuiensis 的化学成分进行研究。方法 采用薄层层析、硅胶柱层析、凝胶柱色谱等分离手段，通过核磁共振等现代波谱技术以及铜靶单晶X-衍射分析，并结合文献数据，对陵水山海绵M. lingshuiensis中的化学成分进行分离和结构鉴定。结果 从陵水山海绵M. lingshuiensis中共分离鉴定了5个含氮化合物，包括4个单吲哚生物碱：3-吲哚甲醛（1），3-吲哚甲酸（2），3-（hydroxylacetyl）-indole（3），4-hydroxy-5-（indole-3-yl）-5-oxo-pentan-2-one（4）和1个核苷：胸苷（5）。结论 化合物1~5均为首次从该种海绵中分离得到。 |
| English Summary: |
| Objective To study the chemical constitutions of sponge Mycale lingshuiensis. Methods The isolation and purification of these compounds were performed via repeated TLC, silica gel column, and Sephadex LH-20 column chromatography. The structures of these compounds were identified by means of spectroscopic methods, X-ray diffraction analysis, and comparison with the data of literatures. Results Five known nitrogenous compounds including four monoindole alkaloids and a nucleoside were isolated from the sponge M. lingshuiensis and their structures were identified as indole-3-carboxaldehyde (1), 3-indolecarboxylic acid (2), 3-(hydroxylacetyl)-indole (3), 4-hydroxy-5-(indole-3-yl)-5-oxo-pentan-2-one (4), and thymidine (5). Conclusions Compounds 1~5 were discovered from the M. lingshuiensis for the first time. |
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