| 聂君环,侯雪梅,白虹,等.柳珊瑚来源真菌Penicillium chrysogenum中聚酮-萜类化合物citrehybridonol及其单晶结构[J].中国海洋药物,2017,36(4):83-86. |
| 柳珊瑚来源真菌Penicillium chrysogenum中聚酮-萜类化合物citrehybridonol及其单晶结构 |
| Meroterpenoid citrehybridonol from gorgonian-derived fungus Penicillium chrysogenum and its crystal structure |
| 投稿时间：2017-02-21 修订日期：2017-03-20 |
| DOI： |
| 中文关键词: 柳珊瑚来源真菌 聚酮-萜类化合物 citrehybridonol X-射线衍射 晶体结构 |
| English Keywords:gorgonian-derived fungus meroterpenoid citrehybridonol X-ray diffraction crystal structure |
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| 中文摘要: |
| 目的 柳珊瑚来源真菌Penicillium chrysogenum中聚酮-萜类化合物citrehybridonol及其晶体结构和生物活性研究。方法 利用核磁、质谱等现代波谱分析方法和X-ray单晶衍射技术,对citrehybridonol的化学结构进行研究；运用细胞毒活性和抗菌活性模型对其生物活性进行评价。结果 citrehybridonol为首次获得其晶体,并首次对其单晶数据进行报道。生物活性测试结果表明,该化合物对测试的细菌菌株未显示抗菌活性,对肿瘤细胞株未见细胞毒活性。结论 citrehybridonol的单晶数据以及活性数据对今后系统研究聚酮-萜类化合物具有参考价值。 |
| English Summary: |
| Objective To study the meroterpenoid, citrehybridonol, isolated from the gorgonian-derived fungus Penicillium chrysogenum, its crystal structure and bioactivity. Methods The chemical structure of citrehybridonol was determined by extensive NMR and MS spectroscopic data, and its stereochemicl structure was established by X-ray diffraction of single crystal. The bioactivities were evaluated by using cytotoxic and antibacterial models. Results The single-crystal data of citrehybridonol was obtained and reported for the first time. Citrehybridonol was found to be inactive against the tested bacteria and cancer cell lines. Conclusions The data of single-crystal and biological activities provided references for the systematic study of citrehybridonol and its analogues in the future. |
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