| 杨琳,唐旭利,李平林.西沙海绵Dysidea granulosa 化学成分研究[J].中国海洋药物,2017,36(5):63-68. |
| 西沙海绵Dysidea granulosa 化学成分研究 |
| Study on the chemical constituents of sponge Dysidea granulosa from the South China Sea |
| 投稿时间：2017-03-14 修订日期：2017-05-08 |
| DOI： |
| 中文关键词: Dysidea granulosa 化学成分；scalarane型二倍半萜；多溴带联苯醚 |
| English Keywords:Dysidea granulosa chemical constituents scalarane sesterterpene Polybrominated Diphenyl. |
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| 中文摘要: |
| 目的 研究中国西沙群岛海绵Dysidea granulosa的化学成分。 方法 利用薄层色谱、硅胶色谱、Sephadex LH-20色谱、MPLC、半制备HPLC等方法对化学成分进行分离纯化；通过NMR、MS等方法，并结合文献，鉴定化合物的结构。结果 从西沙海绵Dysidea granulosa的甲醇粗提取物中，分离得到6个化合物： Honulactone A (1), Honulactone B(2), Honulactone E (3), Honulactone F (4), 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol (5), 3,5-Dibromo-6-chloro-2-(2,4- dibromophenoxy)phenol (6)。结论 化合物1、2、3、4均为首次从该种海绵中分离得到。 |
| English Summary: |
| Objective To investigate the chemical constituents of sponge Dysidea granulosa. Methods The compounds were isolated and purified by TLC, silica gel column, Sephadex LH-20 column chromatography, MPLC and HPLC. Their chemical structures were identified by NMR、MS, and comparison with the data of literatures. Results From the CH3OH extract of Dysidea granulosa, six compounds were isolated and their structures were determined as Honulactone A (1), Honulactone B(2), Honulactone F (3), Honulactone E (4), 2-(2'',4''-Dibromophenoxy)-4,6- dibromophenol (5), 3,5-Dibromo-6-chloro-2-(2,4-dibromophenoxy)phenol (6). Conclusion Compounds 1, 2, 3, 4 were isolated from the Dysidea ganulosa for the first time. |
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