| 张朦,蒋怡菲,张亦然,等.海洋来源Neolamellarin A类似物的神经保护活性[J].中国海洋药物,2018,37(1):80-83. |
| 海洋来源Neolamellarin A类似物的神经保护活性 |
| Neuroprotective Activity of Neolamellarin A Analogues |
| 投稿时间：2017-04-25 修订日期：2017-06-03 |
| DOI： |
| 中文关键词: 生物碱,Neolamellarin A,PC12细胞,神经保护活性 |
| English Keywords:alkaloids neolamellarin A PC12 cells neuroprotective activity |
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| 中文摘要: |
| 目的 生物碱是自然界中普遍存在的一类含氮的碱性有机化合物，其中海洋生物碱因具有广泛的生物活性而受到极大关注。Neolamellarin A是一种来源于海洋动物海绵并具有新颖吡咯类骨架的生物碱。作者认为人们对Neolamellarin A类生物碱的生物活性的认识有限，希望可以通过更多的活性研究对其加以全面的开发。方法 采用细胞毒活性检测（MTT法）及神经细胞保护模型对五中新颖Neolamellarin A的3,4二芳基取代全甲基化类似物进行检测。结果 发现该类3,4二芳基取代全甲基化的Neolamellarin A类似物较弱的细胞毒活性和突出的神经保护活性。结论 实验结果扩展了该类Neolamellarin A类似物潜在的应用方向并丰富了海洋生物碱的生物功能。 |
| English Summary: |
| Objective Alkaloids are a class nitrogenous compounds found in nature. Marine alkaloids deserve great attention with widespread biological activities. Neolamellarin A is a kind of marine alkaloids, possessing bisaryl-pyrrole structural features. There is limited understanding of the biological activity of Neolamellarin class A alkaloids and the exploration of novel biological activity of these compounds is imperative. Methods The 3,4-bisaryl-N-alkylated permethylated analogues of Neolamellarin A were tested by cytotoxic activity assay (MTT) and PC12 neuron-like cell model. Results It was found that the 3,4-bisaryl-N-alkylated permethylated analogues of Neolamellarin A had weaker cytotoxic activity and prominent neuroprotective activity. Conclusion The neuroprotective activities extend the potential application of Neolamellarin A analogues and enrich the biological functions of the marine alkaloids. |
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