张岗,陈军,许莉,等.养殖叶片山海绵 (Mycale phyllophila) 次生代谢产物的研究△[J].中国海洋药物,2018,37(4):17-23.
养殖叶片山海绵 (Mycale phyllophila) 次生代谢产物的研究△
Study on the Secondary Metabolites of the Farmed Mycale phyllophila
投稿时间：2018-02-03  修订日期：2018-04-26
DOI：
中文关键词:  叶片山海绵  化学成分  结构鉴定  养殖海绵
English Keywords:Mycale phyllophila  chemical constituents  identification  cultured sponge
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作者单位E-mail
张岗 厦门医学院 zg@xmmc.edu.cn 
陈军 福建省海陆界面生态环境重点实验室
福建省海陆界面生态环境重点实验室 		 
许莉 厦门市海洋医用天然产物与细胞工程重点实验室  
李国强* 中国海洋大学医药学院 liguoqiang@ouc. edu. cn 
吴彰哲 台湾海洋大学食品科学系  
罗联忠 厦门医学院  
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中文摘要:
      目的 研究养殖叶片山海绵Mycale phyllophila次生代谢产物,为药源海绵规模化养殖和开发提供依据。方法 综合利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、反相ODS柱色谱、半制备液相色谱等分离技术,对化学成分进行分离；结合NMR、MS等光谱方法和文献数据,鉴定化合物的结构。结果 从叶片山海绵的低极性萃取物中,分离鉴定了11个单体化合物：3-吲哚甲醛 (1)、(1H-indol-3-yl) oxoacetamide (2)、3-hydroxyacetyl-indole (3)、3-(2-(1H-indol-3-yl)-2-oxoethyl)-5,6-dihydropyridin-2(1H)-one (4)、胆固醇(5)、麦角甾-5, 24(28)-二烯-3β-醇(6)、胆甾-5, 22-二烯-3β-醇(7)、花生酸 (8)、1-棕榈酸甘油酯(9)、正十六烷基甘油醚 (10)和对羟基苯甲醛 (11)。结论 所有化合物均为首次从叶片山海绵M .phyllophila中获得。
English Summary:
      Objective To investigate the secondary metabolites of the Farmed Mycale phyllophila. Methods Various chromatographic methods, such as Sephadex LH-20 chromatography, reverse phase chromatography and semi-HPLC chromatography were applied for separating compounds whose structures were determined by 1H, 13C spectral data and MS, and by comparing with data reported in literatures. Result From the low polar fraction of M. phyllophila, eleven compounds were isolated and identified as indole-3-carboxaldehyde (1), (1H-indol-3-yl) oxoacetamide (2), 3-hydroxyacetyl-indole (3), 3-(2-(1H-indol-3-yl)-2-oxoethyl)-5,6-dihydropyridin-2(1H)-one (4), cholesterol (5), ergosta-5, 24(28)-diene-3β-ol (6), cholest-5, 22-diene-3β-ol (7), arachidic acid (8), 1-monopalmitin (9), cetyl ethers of glycerol (10) and p-hydroxybenzaldehyde (11), respectively. Conclusion These eleven compounds were isolated from this sponge for the first time.
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