| 潘增玉,康建功,程伟（并列通讯作者）.中国南海海绵Luffariella sp.的次生代谢产物研究[J].中国海洋药物,2018,37(4):52-56. |
| 中国南海海绵Luffariella sp.的次生代谢产物研究 |
| Study on secondary metabolites of sponge Luffariella sp. from the South China Sea |
| 投稿时间：2018-04-06 修订日期：2018-05-15 |
| DOI： |
| 中文关键词: Luffariella sp. 二倍半萜 NF-κB抑制活性评价 |
| English Keywords:Luffariella sp. sesterterpenoid NF–κB inhibitory activity |
| Fund Project: |
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| 中文摘要: |
| 目的 研究中国南海海绵Luffariella sp.的次生代谢产物及生物活性。方法 利用硅胶柱色谱、C-18反相柱色谱,半制备HPLC等方法对海绵提取物进行分离纯化,通过核磁共振、质谱、紫外、红外等波谱学技术,并结合文献理化数据,确定化合物的结构。对分离得到的化合物进行了NF-κB抑制活性评价实验。结果 分离鉴定了6个含α、β-不饱和γ–内酯环的二倍半萜类化合物,结构确定为Hippolide H (1)、Hippolide F (2)、Hippolide G (3)、Hippolide E (4)、6Z-neomanoalide (5)、6E-neomanoalide (6)。在NF-κB抑制活性评价实验中,化合物1、4、6 具有较好的NF-κB抑制活性。结论 南海海绵Luffariella sp.可代谢具有NF-κB抑制活性的二倍半萜类化合物。 |
| English Summary: |
| Objective To investigate the chemical constituents and bioactivity of the South China Sea sponge Luffariella sp. Methods The compounds were isolated and purified by using silica gel column chromatography, C-18 ODS and semi-preparative HPLC chromatography. Their structures were identified by 1D and 2D NMR、MS、UV、IR and comparison with the date of literatures. They were performed an NF-κB inhibitory activity evaluation test. Results Six sesterterpenoids with α、β–unsaturated–γ–lactone ring were isolated from the sponge. Their structures were identified as Hippolide H (1)、Hippolide F (2)、Hippolide G (3)、Hippolide E (4)、6Z-neomanoalide (5)、6E-neomanoalide (6). In the evaluation of NF–κB inhibitory activity, compounds 1, 4 and 6 showed good NF–κB inhibitory activity. |
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