| 徐睿航,何培民,贾睿.大田软海绵酸的毒性、检测及应用的研究进展[J].中国海洋药物,2021,40(1):59-68. |
| 大田软海绵酸的毒性、检测及应用的研究进展 |
| Research progress on the toxicity, detection and application of okada acid (OA)* |
| 投稿时间：2020-05-08 修订日期：2020-07-04 |
| DOI： |
| 中文关键词: 大田软海绵酸(OA) 毒性 检测 阿尔茨海默症(AD) |
| English Keywords:Okadaic acid (OA) toxicity detection Alzheimer"s disease (AD) |
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| 中文摘要: |
| 大田软海绵酸（Okadaic Acid，OA）属于腹泻性贝毒（Diarrhetic shellfish poisons，DSP）的一种，具有分布广泛，危害大等特点。它可以引起人体的腹泻、呕吐等症状，除此之外，越来越多的研究表明OA具有多种毒性，包括细胞毒性，神经毒性，胚胎毒性，肝毒性等。其致毒机理多与其可以特异性抑制几种丝氨酸/苏氨酸蛋白磷酸酶有关。基于OA的这些危害，对OA进行快速，灵敏的检测显得尤为重要，目前应用最多的检测方法有液相色谱-串联质谱法、高效液相色谱法、生物传感器法、酶联免疫吸附试验、蛋白磷酸酶抑制试验等。但这些检测方法都有自己的优缺点，需要进一步完善。虽然OA属于海洋生物毒素的一种，但其在生物医学领域也有很好的应用，在阿尔茨海默症、肿瘤等疾病的研究中发挥着重要作用。本文对近年来OA毒性的研究，OA的检测方法以及OA在科研工作中的应用进行综述，为该毒素更深层次的研究提供参考。 |
| English Summary: |
| Okadaic Acid belongs to a type of diarrhetic shellfish poisons, which is widely distributed and harmful. It can cause diarrhea, vomiting and other symptoms in humans, in addition, a growing number of studies show that OA has a variety of toxicity, including cytotoxic, neurotoxic, embryotoxic, hepatotoxic, and so on. The mechanism of its toxicity is mostly related to its ability to specifically inhibit several serine/threonine protein phosphatases. Based on these hazards of OA, the rapid and sensitive detection of OA is particularly important, the most commonly used assays are Liquid chromatography-tandem mass spectrometry, high performance liquid chromatography, biosensor method, enzyme-linked immunosorbent assay, protein phosphatase inhibition tests, etc. However, these assays have their own advantages and disadvantages and need further improvement. Although OA is a kind of marine biotoxin, it also has a good application in the field of biomedicine and plays an important role in the research of Alzheimer"s disease, cancer and other diseases. In this paper, we review the recent studies on OA toxicity, the detection methods of OA and the application of OA in scientific research, and provide an overview of the toxicity of this toxin. Deeper research provides references. |
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