| 毛宁,徐伟锋,邵长伦,等.一株柳珊瑚来源真菌Penicillium chrysogenum中生物碱化合物研究[J].中国海洋药物,2021,40(2):17-20. |
| 一株柳珊瑚来源真菌Penicillium chrysogenum中生物碱化合物研究 |
| Research on the alkaloids from the gorgonian coral-derived fungus Penicillium chrysogenum |
| 投稿时间：2020-05-27 修订日期：2020-06-05 |
| DOI： |
| 中文关键词: 柳珊瑚共附生真菌；Penicillium chrysogenum；生物碱 阻转异构体 |
| English Keywords:gorgonian coral-derived fungus Penicillium chrysogenum alkaloids atropisomer |
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| 中文摘要: |
| 目的 对一株南海柳珊瑚来源真菌Penicillium chrysogenum（CHNSCLM-0019）中的生物碱类化合物进行研究。方法 综合运用正、反相硅胶柱层析，HPLC及重结晶等方法对真菌粗提物进行分离纯化，并通过现代波谱学方法、单晶衍射及核磁共振变温实验并结合文献对所得化合物进行结构鉴定。结果 鉴定了6个苯并二氮杂卓类生物碱 1–6，分别为7-methoxycyclopenin (1), cyclopenin (2), 7-methoxycyclopeptin (3), (3S)-1, 4-benzodiazepine-2, 5-diones (4), 7-methoxydehydrocyclopeptin (5), (+)-cyclopenol (6); 并通过核磁共振变温实验验证了化合物1以互变阻转异构体形式存在。 结论 柳珊瑚来源真菌P. chrysogenum（CHNSCLM-0019）是苯并二氮杂卓类生物碱的重要来源。 |
| English Summary: |
| Objective To study the alkaloids from the gorgonian coral-derived fungus Penicillium chrysogenum (CHNSCLM-0019). Methods The pure compounds were isolated by Silica gel column chromatography, ODS, HPLC and recrystallization. Their structures were determined by modern spectroscopic methods, X-ray, variable temperature NMR, and comparison with previously reported data. Results The structures of six benzodiazepine alkaloids 1–6 were determined as 7-methoxycyclopenin (1), cyclopenin (2), 7-methoxycyclopeptin (3), (3S)-1, 4-benzodiazepine-2, 5-diones (4), 7-methoxydehydrocyclopeptin (5), and (+)-cyclopenol (6). Compounds 3 and 4 were determined as tautomeric atropisomers. Conclusion The gorgonian coral-derived fungus P. chrysogenum are important sources of benzodiazepine alkaloids. |
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