| 黄冠华,刘序彦,房晨曦,等.小球藻磁性碳中空微球作为药物缓释载体的开发和应用研究[J].中国海洋药物,2023,42(1):57-65. |
| 小球藻磁性碳中空微球作为药物缓释载体的开发和应用研究 |
| Exploration and application of magnetic carbon hollow microsphere prepared from Chlorella sp. as medicine release carrier |
| 投稿时间：2022-01-19 修订日期：2022-03-29 |
| DOI： |
| 中文关键词: 小球藻 磁性 中空微球 水热碳化 药物缓释 |
| English Keywords:Chlorella sp. magnetic hollow microsphere hydrothermal carbonization medicine release |
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| 中文摘要: |
| 利用小球藻细胞壁纤维骨架，通过水热碳化反应，合成了以Fe3O4为内核的磁性中空碳微球。在对磁性中空碳微球的材料表征测试中发现，合成的磁性碳中空微球具有优异的磁响应性能，通过Fourier红外光谱（FTIR）分析检测出微球的疏水性的增加是藻壁纤维素亲水基团，如羧基、氨基均发生不同程度的减少造成的。通过全自动比表面积和孔隙度分析仪检测分析，无磁性碳化微球比表面积为18.924m2/g、微球孔径为19.845nm，有磁性碳化微球比表面积为0.596m2/g，微球孔径为3.054nm。在对诺氟沙星的缓释研究中发现，在pH=7时220 ℃条件下合成的磁性碳中空微球对诺氟沙星装载容量达到186.12 μg（诺氟沙星）/mg（碳微球）,该磁性碳中空微球可以在pH=8的环境中下实现最优的诺氟沙星控释，3.6 h的累积释药率可达到30%。 |
| English Summary: |
| Using the fibrous skeleton of the cell wall of Chlorella, the magnetic hollow carbon microspheres with Fe3O4 as the core were synthesized through hydrothermal carbonization reaction. In the material characterization test of magnetic hollow carbon microspheres, it is found that the synthesized magnetic hollow carbon microspheres have excellent magnetic response performance. Through FTIR analysis, it is detected that the increase of hydrophobicity of the microspheres are caused by the reduction of functional groups carboxyl and amino groups. Through the detection and analysis of the automatic specific surface area and porosity analyzer, the specific surface area of the microspheres is 18.924m2/g and the pore diameter of the microspheres is 19.845nm. The specific surface area of the magnetic carbonized microspheres is 0.596m2/g, and the pore size of the microspheres is 3.054nm. In the sustained release study of norfloxacin, it was found that the magnetic carbon hollow microspheres synthesized at 220℃ reached equilibrium at pH=7 when the adsorption capacity of norfloxacin reached 186.12μg(norfloxacin)/mg (carbon microspheres), the magnetic carbon hollow microspheres can achieve the optimal controlled release process of norfloxacin in an environment of pH=8 and the cumulative release rate of 3.6 hours can reach 30%. |
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