雷衍虎,韦霞,陈颖楠,等.锉海绵属海绵Xestospongia sp.甾体类成分研究[J].中国海洋药物,2023,42(6):55-60.
锉海绵属海绵Xestospongia sp.甾体类成分研究
Study on the steroids from sponge Xestospongia sp.
投稿时间：2022-11-09  修订日期：2023-01-10
DOI：10.13400/j.cnki.cjmd.2023.06.018
中文关键词:  海绵  Xestospongia sp.  甾体
English Keywords:Sponge  Xestospongia sp.  steroids
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作者单位E-mail
雷衍虎 广州中医药大学 20201110612@stu.gzucm.edu.cn 
韦霞 广西医科大学 weixia6994@163.com 
陈颖楠 广州中医药大学 2020064080@stu.gzucm.edu.cn 
何育佩 广州中医药大学 13557395175@163.com 
樊浩 广州中医药大学 20212110040@stu.gzucm.edu.cn 
周逢国 广州中医药大学 20201110534@stu.gzucm.edu.cn 
司徒美霞 广州中医药大学 20201120645@stu.gzucm.edu.cn 
张翠仙* 广州中医药大学中药学院 zhangcuixian@gzucm.edu.cn 
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中文摘要:
      目的 对广西涠洲岛北部湾海域来源的锉海绵属（Xestospongia）海绵中获得的结构新颖、活性良好的甾体类成分进行研究。方法 根据甾体类化合物的结构特性，利用多种柱色谱和高效液相色谱（HPLC）等方法，通过高分辨质谱（HRMS）、核磁共振（NMR）和旋光（ORD）等方法并结合文献对照对化合物进行结构鉴定。结果 从锉海绵属海绵中分离得到9个甾体化合物，分别为7-ketocholesterol (1)、3β-Hydroxy-24-methylene-5-cholesten-7-one (2)、(22E)-3β-Hydroxychoiesta-5,22-dien-7-one (3)、(22E)-3β-Hydroxychiest-5,22-diene-7,24-dione (4)、Dictyopterisin G (5)、Dictyopterisins D (6)、Dictyopterisins E (7)、antrocarine E (8)和Fucosterol (9)。结论 化合物2-8均为首次从该属海绵中分离得到，6和7母核上C-7位为少见的甲氧基，8是首次从海绵中分离得到5-OH和7羰基的甾体化合物。
English Summary:
      Objective The steroids with novel structure and good bioactivities were obtained from the sponge of the genus Xestospongia from the Beibuwan Gulf of Weizhou Island, Guangxi. Methods According to the structural characteristics of steroids, a variety of methods such as column chromatography and HPLC (Semi-preparative High Performance Liquid Chromatography) were separated of steroids; Their structures were determined by NMR (Nuclear Magnetic Resonance), HRMS (High-Resolution Mass Spectrometry), ORD (Optical Rotatory Dispersion) and comparison with the literature data. Results nine steroids were isolated from the sponge X. sp. and identified as 7-ketocholesterol (1), 3β-Hydroxy-24-methylene-5-cholesten-7-one (2), (22E)-3β-HydroxychoIesta-5,22-dien-7-one (3), (22E)-3β-HydroxychIest-5,22-diene-7,24-dione (4), Dictyopterisin G (5), Dictyopterisins D (6), Dictyopterisins E (7), Antrocarine E (8) and Fucosterol (9). Conclusion Compounds 2-8 were isolated from genus Xestospongia for the first time, 6 and 7 have a rare methoxy group on the C7 position, and 8 with 5-OH and a 7-carbonyl group is firstly isolated from sponges.
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