| 刘坤,张文泽,唐旭利,等.西沙海绵Phakellia sp.溴代吡咯生物碱类次级代谢产物研究[J].中国海洋药物,2023,42(6):73-76. |
| 西沙海绵Phakellia sp.溴代吡咯生物碱类次级代谢产物研究 |
| Studies on secondary metabolites of bromopyrrole alkaloidssesquiterpenoids from a Xisha soft coralsponge Phakellia sp. |
| 投稿时间：2022-11-24 修订日期：2023-03-22 |
| DOI：10.13400/j.cnki.cjmd.2023.06.017 |
| 中文关键词: Phakellia sp. 溴代吡咯生物碱 次级代谢产物 |
| English Keywords:Phakellia sp. bromopyrrole alkaloids secondary metabolites |
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| 中文摘要: |
| 目的 对采自西沙群岛的海绵样品Phakellia sp.进行溴代吡咯生物碱类次级代谢产物的研究。 |
| English Summary: |
| Objective To investigate the secondary metabolites of bromopyrrole alkaloidssesquiterpenoids isolated from a sponge Phakellia sp. collected from the Xisha Islands. Methods The secondary metabolites were separated and purified by silica gel column chromatography, TLC, Medium medium pressure preparative HPLC and semi-HPLC column chromatography, and their structures were determined by NMR, MS and other spectral methods, and comparison with previously reported data. Results Ten bromopyrrole alkaloids were isolated from Phakelliaaralemnalia sp. and were identified as 4-bromo-1H-pyrrole-3-carbamide (1), 4-bromopyrrole-2-carboxylicacid (2), 4,5-dibromo-2-pyrrolic acid (3), bromopyrrole alkaloid (4), N-(4, 5-dibromo-2-pyrrole formyl)- methyl acetat (5), N-(4-bromo-2-pyrrole formyl) -β-alanine methyl ester (6), N-(4, 5-dibromo-2-pyrrole formyl) -β-alanine methyl este (7), mukanadin B (8), 9-hydroxy derivative of mukanadin B (9), mukanadin D (10). Conclusion Ten known bromoine pyrrole alkaloids were isolated from Phakellia sp., all of which were discovered for the first time in this genus, and compounds 5, 6 and 7 were the first isolation of this compound from a natural source new natural products. |
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