| 薛莹,周月,张雅慧,等.柳珊瑚来源真菌Penicillium chrysoygenum中的1个新的α吡喃酮发现（英文）[J].中国海洋药物,2024,43(2):29-34. |
| 柳珊瑚来源真菌Penicillium chrysoygenum中的1个新的α吡喃酮发现（英文） |
| A New α-Pyrone from the Gorgonian-Derived Fungus Penicillium chrysogenum |
| 投稿时间：2023-02-26 修订日期：2023-03-09 |
| DOI：10.13400/j.cnki.cjmd.2024.02.001 |
| 中文关键词: 柳珊瑚来源 Penicillium chrysogenum 聚酮 ECD 抗真菌活性 |
| English Keywords:gorgonian-derived fungus Penicillium chrysogenum polyketide ECD, antifungal activity |
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| 中文摘要: |
| 目的 柳珊瑚来源真菌Penicillium chrysogenum (TA10-16)次级代谢产物及其生物活性研究。方法 通过广泛的波谱数据，包括1D/2D NMR，HRESIMS和ECD谱从而确定化合物的结构。结果 共分离获得7个聚酮化合物，包括1个新的α-Pyrone（1）和6个已知化合物（2–7）。化合物1和6对白色念珠菌表现出中等的抗真菌活性，MIC值为12.5 μmol/L，而化合物7对白色念珠菌的MIC值则为25.0 μmol/L。结论 化合物1的结构通过1D/2D NMR、HRESIMS和ECD等综合光谱数据进行了鉴定。同时，通过活性测试，化合物1和6具有潜在的抗真菌活性。 |
| English Summary: |
| Objective The secondary metabolites from the gorgonian-derived fungus Penicillium chrysogenum (TA10–16) and their biological activities. Methods The structure of the compounds were identified by comprehensive spectroscopic data, including 1D/2D NMR, HRESIMS and ECD. Results Seven polyketide compounds were isolated from a marine fungus Penicillium sp., including a new α-Pyrone (1) and six known compounds (2–7). Compounds 1 and 6 showed moderate antifungal activity against Candida albicans with the same MIC values of 12.5 μmol/L, while compound 7 showed weak activity against C. albicans with the MIC value of 25.0 μmol/L. Conclusion The structure of compound 1 was elucidated by comprehensive spectroscopic data including 1D/2D NMR, HRESIMS and ECD. At the same time, compounds 1 and 6 have potential antifungal activity through activity test. |
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