| KHIZAR Hayyat,黄晓菲,王佳祥,等.南极海洋来源真菌 P. crustosum HDN20-1061中2个新的peniphenone类化合物（英文）[J].中国海洋药物,2025,44(6):83-87. |
| 南极海洋来源真菌 P. crustosum HDN20-1061中2个新的peniphenone类化合物（英文） |
| Two new peniphenones derivatives from Antarctic marine-derived fungus Penicillium crustosum HDN20-1061 |
| 投稿时间：2024-04-16 修订日期：2024-08-28 |
| DOI：10.13400/j.cnki.cjmd.2025.06.009 |
| 中文关键词: peniphenone 南极的 海洋来源真菌 Penicillium crustosum 抗菌活性 |
| English Keywords:peniphenone Antarctic marine-derived fungus Penicillium crustosum antibacterial activity |
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| 中文摘要: |
| 目的 利用OSMAC策略研究南极海源真菌青霉Penicillium crustosum HDN20-1061的代谢产物。方法 采用多种培养基发酵确定最终发酵条件,采用反相ODS柱层析和高效液相色谱等方法对菌株HDN20-1061提取物进行化合物分离纯化,采用核磁共振、质谱、ECD和核磁共振计算等方法鉴定化合物结构。 结果 从Penicillium crustosum HDN20-1061中分离到两个新化合物,分别为peniphenone F (1)和peniphenone G (2),并分离到一个已知化合物(3)。化合物1表现出较弱的抗菌活性,MIC值为64 μM。 |
| English Summary: |
| To explore the metabolites of Antarctic marine-derived fungus Penicillium crustosum HDN20-1061 by OSMAC strategy. Methods Multiple medium trials determined fermentation condition and various methods including ODS column and chromatography and semi-preparative HPLC were employed to separate and purify the extracts of strain HDN20-1061. NMR, MS, ECD and NMR calculations were used to determine the structure of compounds. Results Two new compounds, namely peniphenone F (1) and peniphenone G (2), along with one known compound (3) were isolated from the Penicillium crustosum HDN20-1061. Compound 1 exhibited weak antibacterial activity with an MIC value of 64 μM. |
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