| 侯洁雅,任夏,付先军.6种海洋贝壳类中药矿物元素含量测定及特征分析[J].中国海洋药物,2026,(4):-. |
| 6种海洋贝壳类中药矿物元素含量测定及特征分析 |
| Determination and characteristic analysis of mineral elements in six types of marine-derived shell traditional Chinese medicine |
| 投稿时间：2025-03-03 修订日期：2025-04-23 |
| DOI： |
| 中文关键词: 海洋贝壳类中药 矿物元素 ICP-MS 分析评价 |
| English Keywords:Marine-derived shell traditional Chinese medicine mineral element ICP-MS analysis and evaluation |
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| 中文摘要: |
| 目的 旨在分析6种海洋贝壳类中药矿物元素的含量特征，并探讨矿物元素与物种间的相关性。方法 采用电感耦合等离子体质谱法（ICP-MS）对蛤壳、石决明、牡蛎、海螵蛸、珍珠母和瓦楞子的矿物元素含量进行测定，结合相关性分析、主成分分析（PCA）和聚类分析对数据进行综合评价。结果 共检测出46种矿物元素，其中Ca元素含量最高。6种海洋贝壳中药之间有12种矿物元素存在显著性差异（P＜0.05），主成分分析结果表明，Co、Li、Na、Cr、Nb、Mn、Mo、Mg元素是体现6种海洋贝壳类中药差异的特征元素。结合差异矿物元素的生理功能进一步分析表明，贝壳类药效与矿物元素含量分布密切相关。结论 深入探讨了矿物元素含量与海洋贝壳类中药的相关性和差异性，为该类中药的药效评估和质量标准制定提供了科学依据。 |
| English Summary: |
| Objective This study was aimed to analyze the content characteristics of mineral elements in six marine-derived shell-based traditional Chinese medicines (TCMs) and explore the correlation between mineral elements and species. Methods The mineral element content of Meretricis concha cyclinae concha, Haliotidis concha, Ostreae concha, Sepiae endoconcha, Margaritifera concha, and Arcae concha was determined via inductively coupled plasma mass spectrometry (ICP-MS). Correlation analysis, principal component analysis (PCA), and clustering analysis were applied for a comprehensive evaluation of the data. Results A total of 46 mineral elements were identified, with calcium (Ca) being the most abundant. Significant differences (P < 0.05) in the concentrations of 12 mineral elements were observed among the six shell-based TCMs. The principal component analysis (PCA) results indicated cobalt (Co), lithium (Li), sodium (Na), chromium (Cr), niobium (Nb), manganese (Mn), molybdenum (Mo), and magnesium (Mg) as the key elements distinguishing the six species. Further analysis of the physiological roles of these differential mineral elements indicated a close correlation between the pharmacological effects of shell-based TCMs and the distribution of their mineral element content. Conclusion This study provides a comprehensive investigation of the mineral element content, correlations, and differences among shell-based TCMs, offering scientific evidence for their pharmacological evaluation and quality standard formulation. |
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