| 谢念伽,宋妮,王鹏,等.葡萄糖和甘露糖组成的二糖衍生物的合成[J].中国海洋药物,2027,(1):-. |
| 葡萄糖和甘露糖组成的二糖衍生物的合成 |
| Synthesis of disaccharide derivatives composed of glucopyranosyl and mannopyranosyl residues |
| 投稿时间：2025-04-17 修订日期：2025-12-16 |
| DOI： |
| 中文关键词: 葡萄糖醛酸甘露二糖 葡萄甘露二糖 先糖苷化后氧化 葡萄糖醛酸 |
| English Keywords:glucuronosylmannose glucosylmannose post-glycosylation oxidation glucuronic acid |
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| 中文摘要: |
| 目的 为探究由葡萄糖醛酸(GA)和甘露糖(M)组成海洋活性四糖化合物(GAβMαGAβM)的抗帕金森活性构效关系,本研究报道葡萄甘露二糖(GβM)二糖和GAβM苄苷及对溴苄苷衍生的合成。方法 以全乙酰化的葡萄糖和甘露糖为原料,经过保护基操作完成C-2位羟基裸露的甘露糖苄苷和对溴苄苷受体以及葡萄糖硫苷给体的合成后,再通过立体选择性糖苷化反应以及“先糖苷化后氧化”策略完成四个二糖衍生物的合成。结果 以最长线性步骤11-12步,21%-35%的产率完成了四个目标二糖的合成。 |
| English Summary: |
| Objective To explore the structure-activity relationship of the anti-Parkinson activity of marine active tetrasaccharide GAβMαGAβM, composed of glucuronic acid (GA) and mannose (M), this study reports the synthesis of benzyl/p-bromobenzyl GβM and GAβM disaccharides. Methods Using peracetylated glucopyranoside and mannopyranoside, four disaccharide derivatives were synthesized via stereoselective glycosylation and the "Post-glycosylation oxidation C2-OH exposed benzyl/p-bromobenzyl mannopyranoside acceptors and a thioglucoside donor. Results Ultimately, the synthesis of four target disaccharides has been accomplished in 11-12 longest linear steps with 21%-35% overall yields. |
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