| 张润林,李卓怡,赵博,等.基于CiteSpace的岩藻多糖研究现状及未来发展趋势分析[J].中国海洋药物,2027,(1):-. |
| 基于CiteSpace的岩藻多糖研究现状及未来发展趋势分析 |
| A comprehensive analysis of the current research status and future development trends of fucoidan based on Citespace |
| 投稿时间：2025-09-26 修订日期：2025-12-24 |
| DOI： |
| 中文关键词: 岩藻多糖 CiteSpace 文献计量学 可视化分析 |
| English Keywords:fucoidan CiteSpace biliometric visualization analysis |
| Fund Project: |
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| 摘要点击次数: 15 |
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| 中文摘要: |
| 目的 通过系统分析2000—2025年岩藻多糖的相关文献，揭示岩藻多糖从基础研究到应用开发、从化学成分到活性研究的演变路径，并预测未来发展方向，为其开发利用提供理论支持。方法 基于Web of Science（WOS）和中国知网CNKI数据库，检索关键词“fucoidan”“fucan”“岩藻多糖”“岩藻聚糖”“褐藻多糖硫酸酯”等，结合CiteSpace（6.4.R1）对检索得到的中、英文文献进行可视化分析，内容涵盖发文趋势、核心作者、国际合作网络及关键词等。结果 共纳入4 032篇文献，其中英文文献3 630篇，中文文献402篇，近二十年发文量呈逐年增长趋势，研究热点从早期的提取工艺、分离和结构鉴定转向分子机制及临床应用研究。中国海洋大学及中国科学院海洋研究所为核心研究机构。突现分析显示，“纳米颗粒”“肠道菌群”为近几年新兴研究方向。结论 岩藻多糖研究已进入多学科交叉阶段，但受限于结构多样及机制模糊性， 导致其活性作用靶点不明确，未来需结合多组学技术、精准结构修饰及大规模临床试验，突破其在肿瘤免疫治疗与功能性食品中的应用瓶颈。 |
| English Summary: |
| Abstract: Objective This study systematically analyzes the literature on fucoidan published between 2000 and 2025, aiming to trace its evolution from fundamental research to applied development, and from chemical characterization to bioactivity studies, thereby providing a theoretical foundation for its future utilization. Methods Based on the Web of Science (WOS) and CNKI databases, relevant publications were retrieved using the keywords “fucoidan” CiteSpace (6.4.R1) was employed to visualize and analyze the collected Chinese and English literature, with a focus on publication trends, core authors, international collaboration networks, and keyword evolution. Results A total of 4 032 articles were included, consisting of 3 630 in English and 402 in Chinese. Over the past two decades, the annual number of publications has exhibited steady growth. Research focus has shifted from early emphasis on extraction, purification, and structural identification toward molecular mechanisms and clinical applications. Ocean University of China and the Institute of Oceanology, Chinese Academy of Sciences, were identified as leading research institutions. Keyword burst detection revealed that “nanoparticles” and “gut microbiota” have emerged as recent research frontiers. Conclusion Research on fucoidan has entered a multidisciplinary stage; however, its structural diversity and ambiguous mechanisms have hindered the identification of precise bioactive targets. To overcome the bottlenecks in its application for tumor immunotherapy and functional foods, future efforts should integrate multi-omics technologies, precise structural modification, and large-scale clinical trials. |
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